A Functional cra Gene Is Required for Salmonella enterica Serovar Typhimurium Virulence in BALB/c Mice
- 1 June 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (6) , 3772-5
- https://doi.org/10.1128/iai.68.6.3772-3775.2000
Abstract
A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad − , is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad − that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.Keywords
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