The Mammalian Guanine Nucleotide Exchange Factor mSec12 is Essential for Activation of the Sar1 GTPase Directing Endoplasmic Reticulum Export

Abstract
The Sar1 GTPase is an essential component of COPII vesicle coats involved in export of cargo from the endoplasmic reticulum of mammalian cells. To begin to elucidate its mechanism of action, we now r...