CELLULAR CHANGES IN THE ANTERIOR HYPOPHYSIS WITH SPECIAL REFERENCE TO ITS SECRETORY ACTIVITIES

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Abstract
The author discusses genetic relationship among the acido-philic, basophilic, and chromophobic cells of the anterior hypophysis, then relates the following physiological states with relative cell counts and with cytological evidences of secretory activity, in order to identify the cell type responsible for producing each of the secretions of the anterior lobe: post-castration, pregnancy, post-thyroidec-tomy, hyperthyroidism, some special clinical conditions, and conditions produced by the administration of sex hormones. He emphasizes that diminished granule content in a cell, and diminished potency of hypophyseal tissue with respect to a particular secretion when assayed by implantation, which are usually taken as signs of diminished secretory activity, may be interpreted instead as signs of hyper-function.