The synthesis of 2-(functionalized methyl)-1.BETA.-methylcarbapenems.
- 1 January 1988
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 41 (6) , 780-787
- https://doi.org/10.7164/antibiotics.41.780
Abstract
The synthesis of 1.beta.-methylcarbapenems having a ROCH2 substituent at the 2-position is described. Their in vitro antibacterial activity and DHP-I susceptibilities are presented.This publication has 3 references indexed in Scilit:
- Structure-activity relationships in the 2-arylcarbapenem series. Synthesis of 1-methyl-2-arylcarbapenemsJournal of Medicinal Chemistry, 1987
- Syntheses and biological activities of new carbapenem derivatives.The Journal of Antibiotics, 1984
- Metabolism of Thienamycin and Related Carbapenem Antibiotics by the Renal Dipeptidase, Dehydropeptidase-IAntimicrobial Agents and Chemotherapy, 1982