Modulation of Synaptic Transmission in Autonomic Ganglia Mediated via the Activation of Postganglionic Muscarinic Ml Receptors

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Abstract
The facilitatory actions of muscarine on synaptic transmission were measured in rat superior cervical ganglia in vitro. Muscarine (300 nmol/l) induced increases in sub-maximal population action potentials, which were mimicked by the Ml receptor agonist McN-A-343 (1 μmol/l) and antagonized by the Ml receptor antagonist pirenzepine (100 nmol/l) and telenzepine (100 nmol/l), but not by the M2 receptor antagonist AF-DX 116 (1 μmol/l). Slow excitatory postsynaptic potentials recorded from curarized rabbit isolated superior cervical ganglia were also blocked by telenzepine (300 nmol/l) but not by AF-DX 116 (3 μmol/l). It is concluded that Ml receptors mediate the excitatory actions of muscarinic agonists in these sympathetic ganglia.

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