ACUTE HEMOLYTIC ANEMIA DUE TO NEOARSPHENAMINE: REPORT OF A FATAL CASE

1 January 1946

journal article
research article
Published by American College of Physicians in Annals of Internal Medicine

Vol. 24 (1) , 104-111
https://doi.org/10.7326/0003-4819-24-1-104

Abstract

A patient with minimal syphilis of the aorta developed chills, fever, back pain, hemoglobinuria, oliguria and icterus following the 5th injn. of neoarsphenamine. Hemoglobinemia and other findings in the blood and bone marrow confirmed the diagnosis of acute hemolytic reaction. The hepatic and renal lesions appeared to be the result of the hemolytic reaction rather than of the toxicity of neoarsphenamine. Although aplastic anemia, agranulocytosis and thrombocytopenia have been repeatedly described as complications of arsenotherapy, there is no previous record of the occurrence of hemolytic anemia after admin. of any of the arsphenamines.

Keywords

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