Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
- 23 October 1992
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 258 (5082) , 607-614
- https://doi.org/10.1126/science.1411571
Abstract
Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca2+ channels. This was once thought to be the sole mechanism to produce the diacylglycerol that links extracellular signals to intracellular events through activation of protein kinase C. It is becoming clear that agonist-induced hydrolysis of other membrane phospholipids, particularly choline phospholipids, by phospholipase D and phospholipase A2 may also take part in cell signaling. The products of hydrolysis of these phospholipids may enhance and prolong the activation of protein kinase C. Such prolonged activation of protein kinase C is essential for long-term cellular responses such as cell proliferation and differentiation.Keywords
This publication has 166 references indexed in Scilit:
- Purification and characterization of rabbit platelet cytosolic phospholipase A2Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
- Structure of gene coding for rat group II phospholipase A2Biochemical and Biophysical Research Communications, 1990
- Studies on the acyl-chain selectivity of cellular phospholipases A2Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
- Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein controlBiochemical and Biophysical Research Communications, 1989
- Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cellsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
- 12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysatesBiochemical and Biophysical Research Communications, 1988
- Further studies on the specificity of diacylglycerol for protein kinase C activationBiochemical and Biophysical Research Communications, 1987
- Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187Biochemical and Biophysical Research Communications, 1986
- Evidence for a catalytic role of phospholipase A in phorbol diester- and zymosan-induced mobilization of arachidonic acid in mouse peritoneal macrophagesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
- Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombinBiochemical and Biophysical Research Communications, 1980