Adherence of Polymorphonuclear Leukocytes to Nylon: Modulation by Prostacyclin (PGI2), Corticosteroids, and Complement Activation

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Abstract
Effects of in vitro addition of prostacyclin (PGI2) , hydrocortisone, and zymosan to plasma on adherence of polymorphonuclear leukocytes (PMNLs) to nylon were investigated. PGI2, in nanogram concentrations, and hydrocortisone, in high concentrations, inhibited base-line adherence of PMNLs; zymosan-treated plasma augmented retention of PMNLs by nylon columns. Incubation of plasma with antiserum to C5, hydrocortisone, or PGI2 blocked zymosan-mediated effects. Prostaglandins (PGD2, PGE1, and PGF2a) when added in vitro did not alter base-line adherence. PMNLs obtained 4 hr after administration of oral prednisone to volunteers were partially resistant to effects of zymosan-activated plasma.