Dose Profiles in Treatment Planning

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Abstract
Dose profiles are plots of dose as a function of spatial position on a single line through an irradiated volume. Dose was conventionally specified in terms of minimum and/or maximum tumor dose, modal dose, critical normal tissue dose or via isodose display. Dose profiles are useful in evaluating dose uniformity within a tumor volume, dose gradient at the edges of beams or dose within critical organs. To aid in expanding the use of dose profiles, Artronix added a dose profile option to their computer treatment planning system. This program is now under evaluation with a comparison of other methods of dose profile construction. This alternative and adjunctive method of treatment planning was extended to routine use in the construction of beam modifying and beam defining devices. Optimization techniques utilizing appropriate score functions are also being developed. Extension of the concept of tumor profiles (analogous to dose profiles) may allow comparison of current treatment regimens and evaluation of their appropriateness as a function of tumor cell distribution.

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