Alloantibodies that React with Subsets of Human T Cells

Publisher Website
Google Scholar
Abstract
Using the two color fluorescence (TCF) method, alloantibodies against subsets of T cells could be detected in sera from pregnant women with strong HLA antibodies. To preclude interference of these HLA antibodies with the recognition of the T cell antibodies, serum donors were selected which were HLA—Al, —B8, —DRw3. Their sera were tested on a panel of individuals homozygous for HLA—Al, —B8, —DRw3. By enriching peripheral mononuclear blood lymphocytes for Tγ cells it could be shown that some of the sera reacted mainly with Tγ and others with Tμ lymphocytes, while some sera reacted with both.