Metrizoic Acid (Isopaque Coronar) Used in Man for Cardiac Angiography

Abstract
Isopaque Coronar, a radiopaque agent, was given (10,000 injections) to 2028 patients during angiocardiographic studies done over a 3 yr period. With 2 exceptions, all complications occurred during right coronary artery injection. Seven cases of ventricular fibrillation, and 5 of marked bradycardia/asystole, were associated with injection of the medium. Isopaque Coronar is well tolerated by patients during cardiac examinations. Factors which may help to explain the low complication rate are discussed.