Recurrent Glomerulonephritis and Risk of Renal Allograft Loss

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Abstract
The article by Briganti et al. (July 11 issue)1 reminds us that the original renal disease may recur in renal transplants and identifies recurrence of glomerulonephritis as an important cause of late allograft loss. The authors report that mesangiocapillary (or membranoproliferative) glomerulonephritis type I and membranous glomerulonephritis have a high rate of recurrence (14.4 percent and 12.5 percent, respectively). It is well known that these glomerular lesions, particularly membranoproliferative glomerulonephritis type I, are associated with certain chronic viral infections, such as hepatitis C infection. Moreover, chronic infection with hepatitis C virus may also induce such immune-complex–mediated glomerular lesions in the transplant2 and is associated with accelerated allograft loss.3

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