Deletion analysis of p16INKa and p15INKb in relapsed childhood acute lymphoblastic leukemia
Open Access
- 15 June 2002
- journal article
- Published by American Society of Hematology in Blood
- Vol. 99 (12) , 4629-4631
- https://doi.org/10.1182/blood.v99.12.4629
Abstract
This study aimed at determining the prevalence of INK4deletions and their impact on outcome in 125 children with acute lymphoblastic leukemia (ALL) at first relapse using real-time quantitative polymerase chain reaction. Patients were enrolled into relapse trials ALL-REZ BFM (ALL-Relapse Berlin–Frankfurt–Münster) 90 and 96. The prevalence of p16INK4a and p15INK4bhomozygous deletions was 35% (44 of 125) and 30% (38 of 125), respectively. A highly significant association of both gene deletions was found with the 2 major adverse prognostic factors known for relapsed childhood ALL: T-cell immunophenotype and first remission duration. There was no correlation between INK4 deletions and probability of event-free survival. These findings argue against an independent prognostic role of INK4 deletions in relapsed childhood ALL.Keywords
This publication has 18 references indexed in Scilit:
- Prognostic value of p16INK4a gene deletions in pediatric acute lymphoblastic leukemiaBlood, 2001
- Hemizygous p16INK4A deletion in pediatric acute lymphoblastic leukemia predicts independent risk of relapseBlood, 2001
- Gene Dosage by Quantitative Real-Time PCRBioTechniques, 1999
- TaqMan PCR-based Gene Dosage Assay for Predictive Testing in Individuals from a Cancer Family with INK4 Locus HaploinsufficiencyClinical Chemistry, 1999
- Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemiaOncogene, 1997
- Multiplex PCR for simultaneous detection of the most frequent T cell receptor-δ gene rearrangements in childhood ALLLeukemia, 1997
- Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XIILeukemia, 1997
- Shortened survival after relapse in T-cell acute lymphoblastic leukemia patients with p16/p15 deletionsLeukemia Research, 1997
- Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia.Journal of Clinical Oncology, 1997
- Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemiaBlood, 1995