Isolation of a human ceruloplasmin cDNA clone that includes the N‐terminal leader sequence
- 28 July 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 203 (2) , 185-190
- https://doi.org/10.1016/0014-5793(86)80739-6
Abstract
A number of cDNA clones encoding human ceruloplasmin were identified using two mixed oligonucleotide probes. One of these clones was shown by DNA sequence analysis to span from the complete N-terminal leader sequence to 114 amino acids short of the C-terminus. The leader sequence consists of 19 primarily hydrophobic amino acids. Northern blot analysis of RNA from human liver showed two species of ceruloplasmin mRNA; a minor species of 3600 nucleotides and a major one of 4400 nucleotides.Keywords
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