Microsatellite Instability Predicts Improved Response to Adjuvant Therapy With Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B Protocol 89803
Top Cited Papers
- 10 April 2009
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 27 (11) , 1814-1821
- https://doi.org/10.1200/jco.2008.18.2071
Abstract
Purpose Colon cancers exhibiting DNA mismatch repair (MMR) defects demonstrate distinct clinical and pathologic features, including better prognosis and reduced response to fluorouracil (FU) –based...Keywords
This publication has 34 references indexed in Scilit:
- Prognostic and Predictive Roles of High-Degree Microsatellite Instability in Colon Cancer: A National Cancer Institute–National Surgical Adjuvant Breast and Bowel Project Collaborative StudyJournal of Clinical Oncology, 2007
- Systematic Review of Microsatellite Instability and Colorectal Cancer PrognosisJournal of Clinical Oncology, 2005
- Cellular effects of CPT‐11 on colon carcinoma cells: Dependence on p53 and hMLH1 statusInternational Journal of Cancer, 2002
- Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cellsInternational Journal of Cancer, 2001
- Genetic and Epigenetic Modification of MLH1 Accounts for a Major Share of Microsatellite-Unstable Colorectal CancersThe American Journal of Pathology, 2000
- On the Role of DNA Double-Strand Breaks in Toxicity and CarcinogenesisCritical Reviews in Toxicology, 1997
- Frameshift mutator mutationsNature, 1996
- Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite InstabilityScience, 1995
- Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisNature, 1993
- Microsatellite Instability in Cancer of the Proximal ColonScience, 1993