ANABOLIC, ANDROGENIC AND MYOTROPIC ACTIVITIES OF DERIVATIVES OF 7α-METHYL-19-NORTESTOSTERONE

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Abstract
Anabolic, myotropic and androgenic properties of a series of 7[alpha]-methyl-19-nortestosterone derivatives were compared using quantitative monkey anabolic and rat myotropic/androgenic assays. 7[alpha]-Methyl-19-nortestosterone acetate was found to be 6.5 times as potent an androgen as testosterone propionate, and 23 times as potent as a myotropic agent when parenterally administered. The cyclopentylpropionate ester, also more potent than testosterone propionate, possessed depot anabolic and androgenic activity. By oral administration, 7[alpha], 17[alpha]-dimethyl-19-nortestosterone was 14 times as potent as fluoxymesterone as an anabolic agent in monkeys and possessed a monkey anabolic/rat androgenic ratio of 7:1 relative to fluoxymesterone. The free alcohol parent of this series also had high oral activity and possessed a favorable anabolic/androgenic ratio.

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