Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics
- 1 April 1979
- journal article
- research article
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 7 (2) , 227-232
- https://doi.org/10.1007/bf01059740
Abstract
Using an equation for the calculation of plasma profiles of drug based on the zero-order input and Michaelis-Menten kinetic output in a one-compartment open model system, the times required to reach various degrees of several steady-state plasma concentrations of phenytoin are calculated. The effect of the apparent volume of distribution (due to intersubject variation or change in protein and/or tissue binding, etc.) on the time required to reach various fractions of steady-state plasma concentrations is discussed.Keywords
This publication has 15 references indexed in Scilit:
- The clinical pharmacokinetics of phenytoinJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Dose-dependent kinetics of theophylline disposition in asthmatic childrenThe Journal of Pediatrics, 1977
- Pharmacokinetics of Alcohol Following Single Low Doses to Fasted and Nonfasted SubjectsThe Journal of Clinical Pharmacology, 1977
- Phenytoin: Pharmacokinetics and bioavailabilityClinical Pharmacology & Therapeutics, 1976
- Elimination of Alcohol from Human BloodJournal of Pharmaceutical Sciences, 1976
- A Study of the Pharmacokinetics of Phenytoin (Diphenylhydantoin) in Epileptic Patients, and the Development of a Nomogram for Making Dose IncrementsEpilepsia, 1975
- Diphenylhydantoin elimination kinetics in overdosed childrenClinical Pharmacology & Therapeutics, 1975
- Pharmacokinetic study of a patient with diphenylhydantoin toxicityClinical Pharmacology & Therapeutics, 1973
- Acute Intoxication with 5,5-Diphenylhydantoin (Dilantin®) Associated with Impairment of BiotransformationAnnals of Internal Medicine, 1972
- Salicylate Accumulation Kinetics in ManNew England Journal of Medicine, 1972