Sequence of Two mRNAs Encoding Active Rat Tryptophan Hydroxylase

1 July 1988

journal article
research article
Published by Wiley in Journal of Neurochemistry

Vol. 51 (1) , 312-316
https://doi.org/10.1111/j.1471-4159.1988.tb04871.x

Abstract

Two full-length cDNA clones that encode functional rat tryptophan hydroxylase (EC 1.14.16.4), the key enzyme in serotonin synthesis, have been isolated from a rat pineal gland library. These two clones correspond to the 1.8- and 4-kilobase mRNA species, respectively. They contain the same coding sequence corresponding to a 51,010-dalton protein and differ in the length of their 3'' untranslated regions.

Keywords

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