Placebo-controlled efficacy of antidepressants in continuation treatment
- 1 March 1994
- journal article
- research article
- Published by Wolters Kluwer Health in International Clinical Psychopharmacology
- Vol. 9, 49-53
- https://doi.org/10.1097/00004850-199403001-00008
Abstract
All episodes of depression require treatment after symptomatic response of the acute episode in order to consolidate response. If treatment is discontinued early, 30% to 50% of patients will suffer a relapse of the inadequately treated episode. Placebo-controlled studies with a variety of antidepressants, old and new, have provided compelling evidence of the efficacy of antidepressants on relapse prevention. A recent study of citalopram has also shown the need for long-term treatment with anti-depressants in patients whose acute episode of depression appeared to respond to placebo since their response was not maintained.Keywords
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