The Role of Synaptic Proteins in Alzheimer's Disease
- 1 December 2000
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 924 (1) , 68-75
- https://doi.org/10.1111/j.1749-6632.2000.tb05562.x
Abstract
Abstract: Synaptic damage is an early event common to neurodegenerative disorders such as Alzheimer's disease (AD) and is the best correlate to the cognitive impairment found in these patients. Recent studies have shown that several of the molecules involved in neurodegenerative disorders are in fact synaptic proteins with amyloidogenic potential (SPWAP). Here we propose a unified theory to explain the neurodegenerative process in AD based on the idea that abnormal folding and/or aggregation of these molecules leads to cell death. The most important predictions of this hypothesis are that: (1) there are other yet unknown SPWAP that might be involved in AD, and their identity can be predicted by defining what makes a protein amyloidogenic; (2) there are endogenous anti‐amyloidogenic molecules that regulate the aggregation state of SPWAP; and (3) there might be forms of the disease associated with decreased production of endogenous anti‐amyloidogenic molecules or with unbalance of pro‐ versus anti‐amyloidogenic factors.Keywords
This publication has 33 references indexed in Scilit:
- Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesodermNature, 1997
- Immunohistochemical analysis of presenilin‐1 expression in the mouse brainFEBS Letters, 1996
- The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD familiesNature Genetics, 1995
- Characterization of a novel protein regulated during the critical period for song learning in the zebra finchPublished by Elsevier ,1995
- Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.The Journal of Experimental Medicine, 1995
- Apolipoprotein E expression at neuromuscular junctions in mouse, rat and human skeletal muscleFEBS Letters, 1994
- Reduction of Neurological Damage by a Peptide Segment of the Amyloid β/A4 Protein Precursor in a Rabbit Spinal Cord Ischemia ModelExperimental Neurology, 1994
- Secreted Forms of β‐Amyloid Precursor Protein Protect Against Ischemic Brain InjuryJournal of Neurochemistry, 1994
- Prion protein is necessary for normal synaptic functionNature, 1994
- Identification of two distinct synucleins from human brainFEBS Letters, 1994