Reactivity of the pyrido[1,2-a]pyrimidin-4-one ring system
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1753-1756
- https://doi.org/10.1039/p19740001753
Abstract
The reactivity of the pharmacologically active pyrido[1,2-a]pyrimidin-4-one ring system has been investigated, and its ring opening, catalytic hydrogenation, reduction by sodium borohydride, N-alkylation, and bromination are described. The hydrolysis, ammonolysis, and reaction with hydrazine of a 3-ethoxycarbonyl group are also discussed. The reactivity is compared with the charge distribution of the molecules calculated by quantum chemical methods.Keywords
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