BactericidalActivities of Daptomycin, Quinupristin-Dalfopristin, and Linezolidagainst Vancomycin-ResistantStaphylococcus aureusinan In Vitro Pharmacodynamic Model with SimulatedEndocardialVegetations
Open Access
- 1 December 2003
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (12) , 3960-3963
- https://doi.org/10.1128/aac.47.12.3960-3963.2003
Abstract
In search of treatment alternatives against vancomycin-resistant S. aureus (VRSA), an in vitro pharmacodynamic model with simulated endocardial vegetations incorporating protein and a high inoculum was used to simulate daptomycin, linezolid, quinupristin-dalfopristin, and vancomycin against the Michigan VRSA strain. Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA.Keywords
This publication has 30 references indexed in Scilit:
- In Vitro Activities of Quinupristin-Dalfopristin and Cefepime, Alone and in Combination with Various Antimicrobials, against Multidrug-Resistant Staphylococci and Enterococci in an In Vitro Pharmacodynamic ModelAntimicrobial Agents and Chemotherapy, 2002
- Efficacy of Linezolid in Treatment of Experimental Endocarditis Caused by Methicillin-Resistant Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 2001
- Bactericidal Activities of Two Daptomycin Regimens against Clinical Strains of Glycopeptide Intermediate-Resistant Staphylococcus aureus , Vancomycin-Resistant Enterococcus faecium , and Methicillin-Resistant Staphylococcus aureus Isolates in an In Vitro Pharmacodynamic Model with Simulated Endocardial VegetationsAntimicrobial Agents and Chemotherapy, 2001
- Treatment of experimental endocarditis due to erythromycin-susceptible or -resistant methicillin-resistant Staphylococcus aureus with RP 59500Antimicrobial Agents and Chemotherapy, 1995
- In vitro pharmacodynamic effects of concentration, pH, and growth phase on serum bactericidal activities of daptomycin and vancomycinAntimicrobial Agents and Chemotherapy, 1992
- Pharmacokinetics and bactericidal rates of daptomycin and vancomycin in intravenous drug abusers being treated for gram-positive endocarditis and bacteremiaAntimicrobial Agents and Chemotherapy, 1992
- Effect of protein binding of daptomycin on MIC and antibacterial activityAntimicrobial Agents and Chemotherapy, 1991
- Daptomycin disrupts membrane potential in growing Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 1991
- Pharmacodynamics of daptomycin and vancomycin on Enterococcus faecalis and Staphylococcus aureus demonstrated by studies of initial killing and postantibiotic effect and influence of Ca2+ and albumin on these drugsAntimicrobial Agents and Chemotherapy, 1991
- In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibioticAntimicrobial Agents and Chemotherapy, 1986