ENHANCED ANTIPYRINE METABOLISM IN CIGARETTE SMOKERS IN INDIAN POPULATION

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (6) , 269-271
Abstract
A single oral dose of 18 mg/kg body weight of antipyrine was administered to 10 chronic cigarette smokers and to 9 appropriate control healthy volunteers. Plasma antipyrine half-life (t1/2.beta.) was shortened significantly (P < 0.05) in cigarette smokers as compared to the non-smokers control group. Antipyrine was cleared from the blood faster in cigarette smokers, with a mean increase in metabolic clearance rate from 0.637 ml/min per kg in nonsmokers to 0.831 ml/min per kg in cigarette smokers. Concern as to enhanced metabolism of other drugs is probably warranted in cigarette smokers.