MALIGNANT FIBROUS HISTIOCYTOMAS INDUCED BY 4-(HYDROXYAMINO)QUINOLINE 1-OXIDE IN RATS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 68  (5) , 859-865
Abstract
Subcutaneous and bone malignant fibrous histiocytomas (MFH) were induced in high incidence in rats by 4-(hydroxyamino)quinoline-1-oxide (4-HAQO). Subcutaneous MFH were induced locally by repeated weekly injections of 1 mg 4-HAQO/rat for 4 wk. Between 16 and 48 wk after the final treatment, 13/15 (87%) male noninbred Wistar rats developed tumors. The histologic subtypes of these tumors were as follows: 11 fibrous, 1 myxoid and 1 giant cell. Bone MFH were induced between 18 and 25 wk by implantation of 4-HAQO (8 mg/rat) into the bone marrow of the tibia in 12/14 (86%) male noninbred Fischer 344 rats. The histologic subtypes of these tumors were as follows: 6 fibrous, 4 myxoid and 2 giant cell. Morphologically, these MFH appeared similar to human MFH.