Denervation of rat adrenal glands markedly increases preproenkephalin mRNA.
- 1 November 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (22) , 7221-7223
- https://doi.org/10.1073/pnas.81.22.7221
Abstract
The effect of denervation on the expression of rat adrenal proenkephalin has been examined. Following splanchnicectomy there was a several-fold increase in the steady-state levels of preproenkephalin mRNA, which became maximal after 24-48 hr (greater than 10-fold). These results indicate that the previously observed increase in rat adrenal enkephalin-containing peptides following denervation occurs entirely by a pretranslational mechanism. The increase in preproenkephalin mRNA was accompanied by a 50-75% decrease in rat adrenal poly(A)+ RNA. Neural input thus exerts a profound trophic influence on proenkephalin gene expression and RNA metabolism in rat adrenals.This publication has 15 references indexed in Scilit:
- Changes in rat adrenal catecholamines and proenkephalin metabolism after denervation.Proceedings of the National Academy of Sciences, 1984
- Denervated skeletal muscle displays discoordinate regulation for the synthesis of several myofibrillar proteins.Proceedings of the National Academy of Sciences, 1984
- Regulation of apolipoprotein A1 synthesis in avian muscles.Journal of Biological Chemistry, 1983
- A sensitive fluorometric assay for the determination of DNAAnalytical Biochemistry, 1982
- Primary structure of the human Met- and Leu-enkephalin precursor and its mRNANature, 1982
- Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.Proceedings of the National Academy of Sciences, 1980
- Neural control of gene expression in the skeletal muscle fibre: the nature of the lesion in the muscular protein-synthesizing machinery following denervationProceedings of the Royal Society of London. B. Biological Sciences, 1980
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979
- Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medullaNeuroscience, 1978
- Trans-synaptic regulation of tyrosine 3-mono-oxygenase biosynthesis in rat adrenal medullaBiochemical Pharmacology, 1977