EFFECTS OF ANTI-COPPER THERAPY ON HEPATOCELLULAR MITOCHONDRIA IN PATIENTS WITH WILSONS DISEASE - ULTRASTRUCTURAL AND STEREOLOGICAL STUDY

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 71  (3) , 457-461
Abstract
Liver biopsy specimens from 7 patients with Wilson''s disease (hepatolenticular degeneration), obtained before and after 3-5 yr of D-penicillamine therapy, were studied by EM and stereology. The characteristic mitochondrial abnormalities encountered in the hepatocytes of untreated patients were less pronounced or disappeared after treatment in 5 of the 7 patients. Relative mitochondrial volume, surface density of the external mitochondrial membranes, and the number of these profiles/unit area increased, whereas abnormal elevations SGOT [serum glutamic oxalacetic transaminase] and SGPT [serum glutamic-pyruvic transaminase] returned to normal levels.

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