Studies on Isocyanides and Related Compounds: A Novel Synthetic Route to Furan Derivatives
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (08) , 783-785
- https://doi.org/10.1055/s-1993-25940
Abstract
The Passerini reaction between arylglyoxals 1, isocyanides 2, and cyanoacetic acid affords N-substituted 3-aryl-2-cyanoacetoxy-3-oxopropionamides 3, which are cyclized in the presence of triethylamine to give N-substituted 3-aryl-4-cyano-2,5-dihydro-5-oxofuran-2-carboxamides 4Keywords
This publication has 0 references indexed in Scilit: