Effect of Specimen Collection on Routine Coagulation Assays and D-Dimer Measurement

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Abstract
Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer assays are part of the conventional routine coagulation panel. Accurate standardization of both the preanalytical and analytical phases is pivotal to achieving accuracy and precision of results. Routine blood coagulation assays and D-dimer testing strongly influence clinical decision-making because they represent crucial steps in the diagnostic approach to thromboembolic and hemorrhagic disorders and in the monitoring of anticoagulant therapy with heparin or oral anticoagulants.