THE ROLE OF GROWTH HORMONE AND THYROXINE IN NEPHROGENIC HYPERTENSION AND CARDIAC HYPERTROPHY IN HYPOPHYSECTOMIZED RATS

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Abstract
There was no indication of slowly developing hypertension and cardiac hypertrophy in hypophysectomized rats upon treatment with desoxycorticosterone and salt loading following unilateral nephrectomy. This was the case in both younger (less than 100 g) and older (220–260 g) male rats. However, the weight of the heart and kidney, the blood pressure, and the rate and output of the heart of normal and hypophysectomized rats following unilateral nephrectomy and treatment with desoxycorticosterone and salt loading were not too different when the hypophysectomized rats were given growth hormone and thyroxine. This agrees with the earlier conclusion that thyroxine and growth hormone are required in hypophysectomized rats for the development of hypertension and any significant enlargement of the heart, whether from aortic constriction or from nephrogenic causes.