The Effect of Colestipol Hydrochloride on the Bioavailability and Pharmacokinetics of Clofibrate

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Abstract
Colestipol HCl and clofibrate have an additive effect in lowering serum cholesterol levels. The blood levels of clofibrate when given simultaneously with colestipol HCl were studied to see if there was any evidence for drug interaction between the 2 products that might dictate a need for separation of their administration time. After concomitant single-dose administration, the serum p-chlorophenoxyisobutyric acid levels, bioavailability parameters and pharmacokinetic parameters studied provided no evidence for an interaction and suggested that colestipol and clofibrate can be administered concomitantly or at separated intervals according to whichever dosage regimen is deemed advisable by the physician.