A DLST genotype associated with reduced risk for Alzheimer’s disease
- 1 April 1999
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 52 (7) , 1505
- https://doi.org/10.1212/wnl.52.7.1505
Abstract
Article abstract Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial α-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.Keywords
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