Immunoglobulin heavy chain binding protein
- 1 November 1983
- journal article
- Published by Springer Nature in Nature
- Vol. 306 (5941) , 387-389
- https://doi.org/10.1038/306387a0
Abstract
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.Keywords
This publication has 4 references indexed in Scilit:
- A theory of allelic and isotypic exclusion for immunoglobulin genes.Proceedings of the National Academy of Sciences, 1982
- Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.Proceedings of the National Academy of Sciences, 1981
- Evidence that murine pre-B cells synthesise μ heavy chains but no light chainsNature, 1979
- Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.Journal of Biological Chemistry, 1977