Methylenetetrahydrofolate Reductase Polymorphisms, Folate, and Cancer Risk: A Paradigm of Gene-Nutrient Interactions in Carcinogenesis
- 1 July 2000
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 58 (7) , 205-209
- https://doi.org/10.1111/j.1753-4887.2000.tb01863.x
Abstract
Recent epidemiologic studies suggest that common polymorphisms of methylenetetrahydrofolate reductase (MTHFR) with allele frequencies up to 35% in thKeywords
This publication has 30 references indexed in Scilit:
- A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme ActivityMolecular Genetics and Metabolism, 1998
- A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?American Journal of Human Genetics, 1998
- Homocysteine and AtherothrombosisNew England Journal of Medicine, 1998
- C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populationsAtherosclerosis, 1998
- Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysisQJM: An International Journal of Medicine, 1997
- Genetic and nongenetic factors for moderate hyperhomocyst(e)inemiaAtherosclerosis, 1996
- A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductaseNature Genetics, 1995
- Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identificationNature Genetics, 1994
- Prevention of neural tube defects: Results of the Medical Research Council Vitamin StudyPublished by Elsevier ,1991
- The Effects of Alcohol on Folate MetabolismAnnual Review of Medicine, 1982