ÜBER DIE WIRKUNG VON KALHKREIN AUF DIE FUNKTION DES HYPOPHYSE-GONADENSYSTEMS

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Abstract
The effect of kallikrein on the pituitary-gonadal function was investigated in rats. In female rats the ovarian and uterine weights showed a signficant increase after 30 day kallikrein treatment. Adrenal and thyroid weights and tail length increased signficantly only in a few instances. No change in I131 uptake and T/S ratio of the thyroid was noted. In male rats only the prostate and seminal vesicles showed a signficant weight gain but not the other organs. In hypophysectomized rats the weights of ovary, uterus, adrenals and thyroid were not significantly different between the kallikrein group and the control. Pituitary gonadotropic potency as measured by the mouse-uterine weight method was augmented by kallikrein both in male and female rats. It seems reasonable to conclude from these results that kallikrein has an effect to augment the production and release of pituitary gonadotrophin.

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