Directed Denaturation: Room Temperature and Stoichiometric Unfolding of Cytochrome c by a Metalloporphyrin Dimer
- 21 March 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (15) , 4420-4421
- https://doi.org/10.1021/ja028574m
Abstract
Using circular dichroism, UV−vis, and trypsin proteolysis, we have shown how a metalloporphyrin dimer induces the unfolding of a protein, cytochrome c, under physiologically relevant conditions and accelerates its rate of proteolytic degradation.Keywords
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