SODIUM-CITRATE REDUCES THE INCIDENCE OF CORNEAL ULCERATIONS AND PERFORATIONS IN EXTREME ALKALI-BURNED EYES - ACETYLCYSTEINE AND ASCORBATE HAVE NO FAVORABLE EFFECT
- 1 January 1981
- journal article
- research article
- Vol. 21 (3) , 486-490
Abstract
Alkali-burned [rabbit] eyes (45 s, 12 mm, 4 N NaOH) were subjected to topical treatment with 10% ascorbate, 20% acetylcysteine, 10% ascorbate together with 20% acetylcysteine, 10% citrate or Adsorbotear vehicle. Only citrate-treated eyes showed a significant decrease in corneal ulcerations and perforations (17%) compared with ascorbate (88%), acetyleysteine (81%), ascorbate/acetylcysteine (100%) or Adsorbotear (75%). In the citrate-treated eyes there was a significantly reduced incidence of band keratopathy (17%) but an increased incidence of hyphema (100%). Both groups receiving acetylcysteine developed acellular corneal caps, the result of peripheral ulceration undermining the central cornea. Polymorphonuclear neutrophils (PMN) were substantially increased at the base of the cap in the acetylcysteine- and acetylcysteine/ascorbate-treated eyes at day 56. At the end of the experiment, citrate-treated eyes showed substantially fewer stromal PMN than any other group. Topical citrate has a most favorable effect on the incidence of corneal ulceration and perforation after alkali burning.This publication has 3 references indexed in Scilit:
- THE EFFICACY OF ASCORBATE TREATMENT AFTER SEVERE EXPERIMENTAL ALKALI BURNS DEPENDS UPON THE ROUTE OF ADMINISTRATION1980
- TOPICAL ASCORBATE DECREASES INCIDENCE OF CORNEAL ULCERATION AFTER EXPERIMENTAL ALKALI BURNS1978
- ADDITIONAL CLINICAL AND MORPHOLOGICAL OBSERVATIONS ON FAVORABLE EFFECT OF ASCORBATE IN EXPERIMENTAL OCULAR ALKALI BURNS1977