Vav: A potential link between tyrosine kinases and Ras‐like GTPases in hematopoietic cell signaling
- 1 March 1993
- Vol. 15 (3) , 179-183
- https://doi.org/10.1002/bies.950150306
Abstract
The vav proto‐oncogene encodes a 95 kDa protein which is expressed exclusively in hematopoietic cells. Analysis of the deduced amino acid sequence has revealed the presence of a src‐homology 2 (SH2) domain, 2 SH3 domains, a cysteine‐rich region with similarity to protein kinase C, and a region highly similar to proteins with guanine nucleotide exchange activity on ras‐like GTPases. Recent work has shown that vav is tyrosine phosphorylated in response to stimulation of surface membrane receptors in a variety of hematopoietic cell lines. Vav may play a role in hematopoietic cell signaling by coupling tyrosine kinase pathways to ras‐like GTPases through the regulation of guanine nucleotide exchange.Keywords
This publication has 39 references indexed in Scilit:
- Involvement of p21ras in activation of extracellular signal-regulated kinase 2Nature, 1992
- Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifsNature, 1992
- Product of vav proto-oncogene defines a new class of tyrosine protein kinase substratesNature, 1992
- ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSKCell, 1992
- Src-related protein tyrosine kinases and T-cell receptor signallingTrends in Genetics, 1992
- Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinasesCell, 1991
- Stimulation of p21ras upon T-cell activationNature, 1990
- Signal transduction by receptors with tyrosine kinase activityPublished by Elsevier ,1990
- ras GENESAnnual Review of Biochemistry, 1987
- Requirement for c-ras proteins during viral oncogene transformationNature, 1986