Chiral Norbornadienes as Efficient Ligands for the Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Fumaric and Maleic Compounds
- 24 August 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (19) , 3425-3427
- https://doi.org/10.1021/ol048421z
Abstract
[reaction: see text] A rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to fumaric and maleic compounds has been developed. While phosphorus-based chiral ligands fail to induce high stereoselectivity, chiral norbornadiene ligands have proved to be uniquely effective to achieve high enantioselectivity in these 1,4-addition reactions.Keywords
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