Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing
Open Access
- 13 March 2003
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 51 (4) , 1033-1036
- https://doi.org/10.1093/jac/dkg190
Abstract
The level of resistance to fusidic acid among community methicillin-susceptible Staphylococcus aureus (MSSA) isolates in the UK and prescriptions for fusidic acid have both doubled over the past 6 years. It is hypothesized that selective pressure arising from topical use of fusidic acid in the community accounts for this increase. A significant correlation was found between prescribing of fusidic acid and resistance at the practice level (Spearman’s rho = 0.46, 95% confidence interval 0.11–0.71, P = 0.01). Further controlled studies are required to determine whether this association is causal.Keywords
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