Effect of propofol on cerebral blood flow and metabolism in man
Open Access
- 1 March 1988
- journal article
- Published by Wiley in Anaesthesia
- Vol. 43 (s1) , 42-43
- https://doi.org/10.1111/j.1365-2044.1988.tb09067.x
Abstract
Cerebral blood flow, cerebral oxygen consumption, lactate and glucose metabolism were measured in 13 patients during anaesthesia with nitrous oxide, oxygen and enflurane 0.5% and after 30 minutes infusion of propofol. The mean blood concentration of propofol was 4.06μg/ml. Cerebral blood flow decreased by 27.6% and cerebral vascular resistance by 51%. There were no changes in lactate and glucose metabolism. Cerebral oxygen consumption decreased by 18.25%. Changes in the electroencephalograph were related to the blood levels of propofol.Keywords
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