The effect of dosage form on absorption of vitamin A into lymph.

Publisher Website
Google Scholar
Abstract
Some effects of dosage form on absorption of vitamin A into thoracic duct were studied in rats fed vitamin A. Of administered vitamin A, 45% was recovered in lymph when vitamin A was given in micellar solution form, while 29% of administered vitamin A was recovered when vitamin A was given in triolein solution form. The time courses of appearance of vitamin A in lymph of these 2 kinds of preparation were very different from one another. Vitamin A appearance in lymph showed a sharp peak between 1-2 h after micellar solution form administration and indicated the almost complete absorption of vitamin A, while it showed a broad band over 4 h after the administration in oily solution form. The time course of vitamin A in serum did not exactly reflect those in lymph.