The Potential Role of Buprenorphine in the Treatment of Opioid Dependence in HIV-Infected Individuals and in HIV Infection Prevention
Open Access
- 15 December 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 43 (Supplement) , S178-S183
- https://doi.org/10.1086/508181
Abstract
Untreated opioid dependence is a major obstacle to the successful treatment and prevention of human immunodeficiency virus (HIV) infection. In this review, we examine the interwoven epidemics of HIV infection and opioid dependence and the emerging role of buprenorphine in improving HIV treatment outcomes among infected individuals, as well as its role in primary and secondary prevention. This article addresses some of the emerging issues about integrating buprenorphine treatment into HIV clinical care settings and the various strategies that must be considered. Specifically, it addresses the role of buprenorphine in improving HIV treatment outcomes through engagement in care, access to antiretroviral therapy and preventive therapies for opportunistic infections, and the potential benefits of and pitfalls in integrating buprenorphine into HIV clinical care settings. We discuss the key research questions regarding buprenorphine in the area of improving HIV treatment outcomes and prevention, including a review of published studies of buprenorphine and antiretroviral treatment and currently ongoing studies, and provide insight into and models for integrating buprenorphine into HIV clinical care settings. Dialogue among practitioners and policy makers in the HIV care and substance abuse communities will facilitate an effective expansion of buprenorphine and ensure that these beneficial outcomes are achieved.Keywords
This publication has 66 references indexed in Scilit:
- Physician Beliefs About Substance Misuse and Its Treatment: Findings from a U.S. Survey of Primary Care PractitionersSubstance Use & Misuse, 2005
- Adherence to Heroin Dependence Therapies and Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Infection Rates among Drug AbusersClinical Infectious Diseases, 2003
- The cost–effectiveness of buprenorphine maintenance therapy for opiate addiction in the United StatesAddiction, 2001
- Detrimental Effects of Continued Illicit Drug Use on the Treatment of HIV-1 InfectionJAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
- Factors Influencing Physicians’ Judgments of Adherence and Treatment Decisions for Patients with HIV DiseaseMedical Decision Making, 2001
- Predictors of Nonadherence to HIV‐Related Medication Regimens During Methadone StabilizationThe American Journal on Addictions, 2001
- Predictors of adherence to tuberculosis treatment in a supervised therapy programme for prisoners before and after release. Study Group of Adherence to Tuberculosis Treatment of PrisonersEuropean Respiratory Journal, 1998
- Integrating Primary Care and Methadone Maintenance Treatment: Implementation IssuesJournal of Addictive Diseases, 1997
- Treatment of Heroin Addicts Using BuprenorphineThe American Journal of Drug and Alcohol Abuse, 1991
- An Outbreak of Community-AcquiredPneumocystis cariniiPneumoniaNew England Journal of Medicine, 1981