G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients
- 5 May 2005
- journal article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 111 (6) , 351-352
- https://doi.org/10.1111/j.1600-0404.2005.00383.x
Abstract
Objective – To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD). Methods – We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients. Results – None of the 237 samples showed the G309D or W437OPA mutations. Conclusions – The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.Keywords
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