Astrocytic Processes: A Route Between Vessels and Neurons Following Blood-Brain Barrier Injury
- 1 July 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Neuropathology and Experimental Neurology
- Vol. 34 (4) , 324-334
- https://doi.org/10.1097/00005072-197507000-00002
Abstract
The fluorescent tracer Evans blue EB was studied after circulation time ranging from 30 seconds to 5 minutes following blood-brain barrier BBB injuries in 42 dogs. Selective neuronal stainings SNS, associated with BBB injuries, occurred to a high degree. This phenomenon was examined by modifications in existing fluorescence techniques. The mechanism of SNS was seen to lie in an almost imperceptible transport of EB along astrocytic processes connecting SNS with the adjacent vasculature. This report presents visual evidence under pathological conditions, and supports the concept of astrocytic processes as the normal route of transport between blood vessels and neurons. This requires long exposure photomicrographs since the fluorescing material is subtle within the neuroglial processes.Keywords
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