Studies on Heart Lymph

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Abstract
Areskog, N.‐H., G. Arturson and G. Grotte. Studies on heart lymph. I. Kinetics of 131I‐albumin in dog heart‐lung Preparations. Acta physiol. scand. 1964. 62.209–217. — The transport of 131I‐albumin from plasma to lymph was studied in dog heart‐lung preparations. Cannulation of a lymph vessel mainly draining the left ventricle was performed. After injection of the labelled substance, plasma mixing was complete within a few minutes. The plasma concentration of the tracer was constant for 2–3 hours. During this time plasma and heart‐lymph samples were collected. The increase in the concentration of the labelled substance in heart‐lymph showed a time course indicating that the substance from the intra‐vascular compartment was mainly distributed to a single extra‐vascular compartment. The data could thus be fully explained by a two‐compartment model and the permeability constants and the size of the extra‐vascular albumin space drained by the lymphatic canola could be calculated.The present experimental approach therefore allowed a “quantitative lymph experiment”, i. e. the size of the extra‐vascular albumin space drained by a lymphatic cannula could be defined and also an idea of the amount of albumin filtered across the capillary walls and the rate of removal of albumin from the extra‐vascular space via the lymphatics was obtained.