Plasma protein binding of penbutolol in pregnancy

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Abstract
Penbutolol is a not cardioselective beta-adrenergic blocking drug; it is lipid soluble and differs in its protein binding from the other members of its group because shows linkage to alpha1-glycoprotein, with no detectable binding to albumin. A A G levels change during pregnancy and so the binding of [3H]-penbutolol was compared in 11 pregnant patients and in 10 healthy women. Binding was obtained by ultrafiltration and measurement of the free fraction by scintillation spectrometry. The free penbutolol fraction was significantly higher in the pregnant women than in the controls ( 6.06±0.34 compared with 3.55±0.29, P< 0.001).The AAG levels in the pregnant women were significantly lower (0.40±0.03g/1) than in the controls (0.77±0.06 g/l) (P1a for AAG was lower in pregnant women, and this suggests that the fall in AAG levels is not the only factor involved in the reduced binding of penbutolol in pregnancy.