Lymphocyte Subpopulations in Man: Relationship between Four Subpopulations Identified by Membrane Markers

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Abstract
The interrelationship between 4 subpopulations of human lymphocytes was studied in 8 normal persons. Double marking and fractionation experiments established that lymphocytes with receptors for AET[2-amino ethylisothiouronium bromide]-treated sheep erythrocytes constitute a population complementary to cells that carry surface membrane immunoglobulins [Ig] as they are identified by polyvalent rabbit anti-human Ig. The latter includes nearly all cells with complement receptors. Two functionally different receptors for antigen-bound IgG were identified by their binding avidity for rabbit-antibody-sensitized ox erythrocytes, defining populations of lymphocytes with high-avidity and low-avidity receptors, indicating 2 valuable differentiation markers.