Theophylline—Use and Misuse in Pediatric Asthma

Abstract
Theophylline is an important agent in the treatment of both chronic and acute asthma in children. However, the great variability in response, the narrow therapeutic range, and the high potential for toxicity can be problems. The clinician must be alert to the variables, individually titrate the dose, and closely monitor the patient's response throughout the course of therapy.