Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
- 1 November 1992
- journal article
- Published by Springer Nature in Nature
- Vol. 360 (6400) , 163-166
- https://doi.org/10.1038/360163a0
Abstract
Glutamate is important in several forms of synaptic plasticity such as long-term potentiation, and in neuronal cell degeneration. Glutamate activates several types of receptors, including a metabotropic receptor that is sensitive to trans-1-amino-cyclopenthyl-1,3-dicarboxylate, coupled to G protein(s) and linked to inositol phospholipid metabolism. The activation of the metabotropic receptor in neurons generates inositol 1,4,5-trisphosphate, which causes the release of Ca2+ from intracellular stores and diacylglycerol, which activates protein kinase C. In nerve terminals, the activation of presynaptic protein kinase C with phorbol esters enhances glutamate release. But the presynaptic receptor involved in this protein kinase C-mediated increase in the release of glutamate has not yet been identified. Here we demonstrate the presence of a presynaptic glutamate receptor of the metabotropic type that mediates an enhancement of glutamate exocytosis in cerebrocortical nerve terminals. Interestingly, this potentiation of glutamate release is observed only in the presence of arachidonic acid, which may reflect that this positive feedback control of glutamate exocytosis operates in concert with other pre- or post-synaptic events of the glutamatergic neurotransmission that generate arachidonic acid. This presynaptic glutamate receptor may have a physiological role in the maintenance of long-term potentiation where there is an increase in glutamate release mediated by postsynaptically generated arachidonic acid.Keywords
This publication has 30 references indexed in Scilit:
- NMDA receptors - their role in long-term potentiationPublished by Elsevier ,2003
- An Ion Channel Locus for the Protein Kinase C Potentiation of Transmitter Glutamate Release from Guinea Pig Cerebrocortical SynaptosomesJournal of Neurochemistry, 1991
- Sequence and expression of a metabotropic glutamate receptorNature, 1991
- Pharmacological and functional characteristics of metabotropic excitatory amino acid receptorsTrends in Pharmacological Sciences, 1990
- The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal DeathAnnual Review of Neuroscience, 1990
- The glutamate receptor of the Qp-type activates protein kinase C and is regulated by protein kinase CNeuroscience Letters, 1990
- A glutamate receptor regulates Ca2+ mobilization in hippocampal neurons.Proceedings of the National Academy of Sciences, 1988
- Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cellsNeuropharmacology, 1988
- A new type of glutamate receptor linked to inositol phospholipid metabolismNature, 1987
- Glutamate stimulates inositol phosphate formation in striatal neuronesNature, 1985