CHEMOPROPHYLAXIS WITH DIAMFENETIDE AGAINST EXPERIMENTAL INFECTIONS OF FASCIOLA-HEPATICA IN RUMINANTS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (2) , 179-182
Abstract
In limited trials against experimentally induced F. hepatica infections, diamfenetide (N,N''-[oxybis(2,1-ethanediyloxy-4,1-phenylene)]bisacetamide) showed potential for prevention of acute fascioliasis in sheep and cattle. When given at a dosage of 10 mg/kg body wt, diamfenetide was 87% effective in preventing establishment of F. hepatica infections in sheep given the drug daily for 14 days and 96% effective in sheep given the drug for 21 days. Infective cysts (4 doses of 150 each) were given by capsule at 2 day intervals during the 1st wk of medication. Initial single large doses (40-100 mg/kg of body wt) given in conjunction with small doses each day (5-40 mg/kg) did not augment chemoprophylactic action. Signs of toxicosis attributable to diamfenetide were not observed. The severity of hepatic lesions ascribable to F. hepatica correlated well with the degree of fluke control achieved. Small doses of diamfenetide given each day were less effective in calves than in sheep. When given at dosages of 30 mg/kg daily for 21 days, the drug was 89% effective in preventing the development of F. hepatica infections in 2 calves given infective cysts (4 .times. 100) by capsule at 2 day intervals during the 1st wk of medication. Small doses of diamfenetide given daily were effective in preventing the establishment of F. hepatica infections in ruminants.

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